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Childhood condition poses risk for Parkinson’s disease later in life

Childhood condition poses risk for Parkinson’s disease later in life

In recent years, defects in the glucocerebrosidase (GBA) gene have been identified as significant risk factors for Parkinson’s disease and deficiencies in this gene also are known to cause Gaucher disease, a lysosomal storage disorder. These separate findings prompted researchers at Baylor College of Medicine to investigate whether changes in lysosome storage disorder genes in … Continue reading

The multi-tasking nature of the hormone asprosin

The multi-tasking nature of the hormone asprosin

When Dr. Atul Chopra, a medical geneticist at Baylor College of Medicine, and his colleagues discovered in 2016 a new hormone called asprosin that regulates blood-glucose levels, the possibilities opened for future treatments that could potentially benefit millions of people living with type 2 diabetes. Asprosin’s reach, however, goes beyond promoting hepatic glucose production. A … Continue reading

How infrequent seizures may lead to persistent memory loss in Alzheimer’s disease

How infrequent seizures may lead to persistent memory loss in Alzheimer’s disease

Even relatively infrequent seizures can lead to long-lasting cognitive deficits in animal models of Alzheimer’s disease; how this happens, however, has been difficult to explain. In her lab at Baylor College of Medicine, Dr. Jeannie Chin, assistant professor of neuroscience, and her colleagues have uncovered a mechanism that offers an explanation to this puzzle. “We … Continue reading

Friend and foe; histamine mediates allergies and can fight colorectal cancer

Friend and foe; histamine mediates allergies and can fight colorectal cancer

Previous studies have shown that histamine is not only involved in allergic disease, it also may have a potential antitumor effect. At Baylor College of Medicine, the lab of Dr. James Versalovic, Milton J. Finegold Professor of pathology and immunology and pathologist-in-chief at Texas Children’s Hospital investigated whether the probiotic Lactobacillus reuteri 6475, which is … Continue reading

Atoh1, a potential Achilles’ heel of Sonic Hedgehog MB

Atoh1, a potential Achilles’ heel of Sonic Hedgehog MB

Medulloblastoma is the most common type of solid brain tumor in children. Current treatments offer limited success and may leave patients with severe neurological side effects, including psychiatric disorders, growth retardation and cognitive impairment. Sonic Hedgehog, one of the four biologically distinct subtypes of medulloblastoma, is named after the cellular pathway that is impaired in … Continue reading