Missing “copy” of Jag1 gene results in mouse model for Alagille syndrome

Missing “copy” of Jag1 gene results in mouse model for Alagille syndrome

By Julia Parsons  When mice usually used in studies of genetic disease lack a copy of the jagged gene (Jag1), they have many of the characteristics, including bile duct abnormalities, of human Alagille syndrome, a developmental disorder characterized by bile duct and cardiovascular defects, as well as abnormalities in other organs, reported Baylor College of … Continue reading

Normal levels of “Goldilocks” protein in mouse model restores neurologic function in MECP2 duplication syndrome

Normal levels of “Goldilocks” protein in mouse model restores neurologic function in MECP2 duplication syndrome

By Ruth SoRelle, M.P.H. For 15 years and more, Dr. Huda Zoghbi, professor of molecular and human genetics at Baylor College of Medicine, and director of the Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital, and her team have worked with the “Goldilocks” protein, MeCP2. Too little of the protein results in Rett … Continue reading

Image of the Month: Mouse breast tumor cells

Image of the Month: Mouse breast tumor cells

Mouse mammary carcinoma 4T1 cells in pseudo-colored scanning electron micrographs. These mouse breast tumor cells (shown in these pseudo-colored scanning electron micrograph, are used to create immunocompetent models of breast cancer with high rates of metastasis or spread. This is a laboratory models used to test new immune therapies against the disease and to study … Continue reading