Friend and foe; histamine mediates allergies and can fight colorectal cancer

Friend and foe; histamine mediates allergies and can fight colorectal cancer

Previous studies have shown that histamine is not only involved in allergic disease, it also may have a potential antitumor effect. At Baylor College of Medicine, the lab of Dr. James Versalovic, Milton J. Finegold Professor of pathology and immunology and pathologist-in-chief at Texas Children’s Hospital investigated whether the probiotic Lactobacillus reuteri 6475, which is … Continue reading

Atoh1, a potential Achilles’ heel of Sonic Hedgehog MB

Atoh1, a potential Achilles’ heel of Sonic Hedgehog MB

Medulloblastoma is the most common type of solid brain tumor in children. Current treatments offer limited success and may leave patients with severe neurological side effects, including psychiatric disorders, growth retardation and cognitive impairment. Sonic Hedgehog, one of the four biologically distinct subtypes of medulloblastoma, is named after the cellular pathway that is impaired in … Continue reading