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Atoh1, a potential Achilles’ heel of Sonic Hedgehog MB

Atoh1, a potential Achilles’ heel of Sonic Hedgehog MB

Medulloblastoma is the most common type of solid brain tumor in children. Current treatments offer limited success and may leave patients with severe neurological side effects, including psychiatric disorders, growth retardation and cognitive impairment. Sonic Hedgehog, one of the four biologically distinct subtypes of medulloblastoma, is named after the cellular pathway that is impaired in … Continue reading

How having too much or too little of CHRNA7 can lead to neuropsychiatric disorders

How having too much or too little of CHRNA7 can lead to neuropsychiatric disorders

Studying the genetic code allows researchers to know whether some patients with neuropsychiatric disorders either have extra copies of the CHRNA7 gene or are missing copies. However, little was known about the functional consequences of this genetic imbalance in brain cells. “For several years we have been studying patients with these conditions in different ways … Continue reading

Analyzing cryo-electron tomography images just got faster

Analyzing cryo-electron tomography images just got faster

Researchers use cryo-electron tomography to visualize macromolecules frozen in action and details of structures inside of cells. This method provides 100 times better resolution than the best light microscope; this information cannot be obtained by any other current method. “However, the need for about one man-week of effort to manually annotate all of the 3-D … Continue reading