A powerful, fast experimental approach identifies potentially safer substitutes for BPA

A powerful, fast experimental approach identifies potentially safer substitutes for BPA

Health concerns about bisphenol A (BPA), or BPA substitutes, have emerged because, according to a National Health and Nutrition Examination Survey, BPA is widespread in human populations.  BPA can leach into canned foods or bottled water, and enter people’s bodies when they consume those foods.  Further concern comes from animal experiments showing that even low-dose … Continue reading

‘Listening’ to single cells may uncover cancer origins

‘Listening’ to single cells may uncover cancer origins

Listening to a single voice in a crowd can be difficult. In a similar way, determining gene expression in single cells has posed quite a challenge.  A major step toward single-cell analysis can potentially help scientists study how cancerous tumors begin, which could lead to better treatments, diagnosis and prevention in the future. “Cancer begins with … Continue reading

“Freeze-frame” synthetic proteins capture DNA events leading to cancer

“Freeze-frame” synthetic proteins capture DNA events leading to cancer

Cancer scientists have focused on identifying signature genetic changes present in cancerous cells and understanding how these changes lead to cancer. Although this approach has delivered important advances, at Baylor College of Medicine Dr. Susan Rosenberg and colleagues wanted to get closer look at how these changes happen. “In my lab we study how the … Continue reading

How understanding tumor diversity can potentially improve the outcomes of patients with lung cancer

How understanding tumor diversity can potentially improve the outcomes of patients with lung cancer

[See video below] “People may think of lung cancer as one disease, but lung cancer is a collection of diverse subtypes of cells and each subtype may respond differently to the same therapy,” said Dr. Chad Creighton, associate professor of medicine and member of the Dan L Duncan Comprehensive Cancer Center Division of Biostatistics at … Continue reading

Targeting two cell surface molecules can mitigate escape of solid glioblastoma tumors

Targeting two cell surface molecules can mitigate escape of solid glioblastoma tumors

One strategy to fight cancer cells involves ‘training’ the individual’s own immune system to fight the tumor, what is called immunotherapy. One form of immunotherapy involves ‘teaching’ the immune cells to recognize molecules on the cancer cell surface in ways that would lead to tumor destruction or better tumor control. Which cell surface molecules to … Continue reading

Altered metabolism in castration-resistant prostate cancer may point to new therapies

Altered metabolism in castration-resistant prostate cancer may point to new therapies

Advanced prostate cancer is usually treated by removing androgen, the male hormone that helps it grow. Although initially effective, this treatment often leads to the tumor becoming castration resistant — it is able to grow without androgen, a lethal condition. Researchers from Baylor College of Medicine and University of Michigan, along with collaborators in other … Continue reading