Childhood condition poses risk for Parkinson’s disease later in life

Childhood condition poses risk for Parkinson’s disease later in life

In recent years, defects in the glucocerebrosidase (GBA) gene have been identified as significant risk factors for Parkinson’s disease and deficiencies in this gene also are known to cause Gaucher disease, a lysosomal storage disorder. These separate findings prompted researchers at Baylor College of Medicine to investigate whether changes in lysosome storage disorder genes in … Continue reading

Image of the Month: Mouse embryo imaged with confocal microscopy

Image of the Month: Mouse embryo imaged with confocal microscopy

The Optical Imaging and Vital Microscopy Core Facility at Baylor College opens a window into the microscopic world through a number of methods, state-of-the-art instrumentation and cutting-edge imaging/image analysis tools for the research applications of Baylor College of Medicine investigators. “Our core is dedicated to 3-D imaging of complex systems and high-resolution investigations of living … Continue reading

Friend and foe; histamine mediates allergies and can fight colorectal cancer

Friend and foe; histamine mediates allergies and can fight colorectal cancer

Previous studies have shown that histamine is not only involved in allergic disease, it also may have a potential antitumor effect. At Baylor College of Medicine, the lab of Dr. James Versalovic, Milton J. Finegold Professor of pathology and immunology and pathologist-in-chief at Texas Children’s Hospital investigated whether the probiotic Lactobacillus reuteri 6475, which is … Continue reading

Atoh1, a potential Achilles’ heel of Sonic Hedgehog MB

Atoh1, a potential Achilles’ heel of Sonic Hedgehog MB

Medulloblastoma is the most common type of solid brain tumor in children. Current treatments offer limited success and may leave patients with severe neurological side effects, including psychiatric disorders, growth retardation and cognitive impairment. Sonic Hedgehog, one of the four biologically distinct subtypes of medulloblastoma, is named after the cellular pathway that is impaired in … Continue reading