One atom can make a difference: Hydrogen-bonding pairing helps design better drugs to neutralize gut bacterial infections

One atom can make a difference: Hydrogen-bonding pairing helps design better drugs to neutralize gut bacterial infections

IP6, the natural inhibitor or ligand of Clostridium difficile’s toxin, binds weakly to the toxin. This results in the toxin remaining active (center figure). Changing a single atom in IP6 to form IP6(S) results in stronger binding to the toxin and its inactivation (left side figure). Credit: T. Savidge, Baylor College of Medicine; K. Prince, … Continue reading

Baylor College of Medicine to develop Emergency Smart Pod

Baylor College of Medicine to develop Emergency Smart Pod

By Dipali Pathak Baylor College of Medicine’s Emergency Smart Pod was one of 12 ideas selected for President Barack Obama’s challenge to find innovative tools to help fight the Ebola crisis and other public health emergencies around the world. The selection was announced by The United States Agency for International Development (USAID). The Emergency Smart … Continue reading

A bacterial signal activates the immune system against rotavirus

A bacterial signal activates the immune system against rotavirus

A bacterial signal activates the immune system against rotavirus By Ruth SoRelle, M.P.H. For three decades, Dr. Mary Estes, professor of molecular virology and microbiology at Baylor College of Medicine has studied the important rotavirus in her laboratory, seeking ways to fight the gastrointestinal disease that causes severe dehydration and roughly half a million deaths … Continue reading