Device that induces a mild localized ‘fever’ could treat vascular involvement in cancer

Device that induces a mild localized ‘fever’ could treat vascular involvement in cancer

The prognosis of a cancer patient relies significantly on the ability of the surgeon to remove all the tumor, including a cancer-free boundary, leaving what surgeons call a tissue margin negative for cancer cells. But this is not always possible. Leaving tumor tissue behind reduces the patient’s chance for recovery because the unremoved tumor may … Continue reading

Out of the body and into bone-in culture: new technique tests drugs for metastatic cancer

Out of the body and into bone-in culture: new technique tests drugs for metastatic cancer

For many cancer patients, the problem is metastasis – the dissemination of tumor cells to other organs – after the primary tumor has been eliminated. Metastases, however, tend to respond differently than the primary tumor to the treatment in part due to residing in a different organ with a different microenvironment. Recreating biological microenvironments in … Continue reading

How breast cancer can become resistant to hormone therapy

How breast cancer can become resistant to hormone therapy

Despite the overall success of hormone therapy, breast cancer tumors in patients with metastatic disease often fail to respond. One new mechanism that can explain resistance to hormone therapy in breast cancer involves two significant changes in the cells – overexpression of the FOXA1 gene and increased production of IL-8. A cluster of breast cancer … Continue reading

Mouse model shows that Notch activation can drive metastatic prostate cancer

Mouse model shows that Notch activation can drive metastatic prostate cancer

Nearly 200 thousand men are diagnosed with prostate cancer every year. Most of the deaths associated with prostate cancer occur in advanced stages of the disease, which are the result of metastasis – the spreading of the tumor away from its origin. Notch signaling pathway is involved in prostate cancer and, in a paper published … Continue reading