New oncogene MNX1 contributes to higher incidence of prostate cancer among African American men

New oncogene MNX1 contributes to higher incidence of prostate cancer among African American men

Genetic factors can explain, at last in part, the higher incidence of prostate cancer among African American men compared with men of other ethnic groups. A team of scientists has identified MNX1 as a new oncogene – a gene than can cause cancer – that is more active in African American prostate cancer than in … Continue reading

Altered metabolism in castration-resistant prostate cancer may point to new therapies

Altered metabolism in castration-resistant prostate cancer may point to new therapies

Advanced prostate cancer is usually treated by removing androgen, the male hormone that helps it grow. Although initially effective, this treatment often leads to the tumor becoming castration resistant — it is able to grow without androgen, a lethal condition. Researchers from Baylor College of Medicine and University of Michigan, along with collaborators in other … Continue reading

Mouse model shows that Notch activation can drive metastatic prostate cancer

Mouse model shows that Notch activation can drive metastatic prostate cancer

Nearly 200 thousand men are diagnosed with prostate cancer every year. Most of the deaths associated with prostate cancer occur in advanced stages of the disease, which are the result of metastasis – the spreading of the tumor away from its origin. Notch signaling pathway is involved in prostate cancer and, in a paper published … Continue reading